The corpus callosum is the major connection between the two hemisphere of the brain and, accordingly, it is the main channel for communication between the two halves. In the 1980s a series of influential publications suggested that the corpus callosum is actually bigger in left and mixed handers when compared with right handers. Since then, callosal differences due to handedness are commonly referred to when behavioural differences between handedness groups have to be explained. However, in a recent meta-analysis and in a separate empirical study, we were able to show that the effects of handedness are small and likely negligible for behaviour. A recording of a presentation of the findings at the North Sea Laterality meeting 2022 in Bergen, can be found here (youtube).